NAE1 / APPBP1

NEDD8 activating enzyme E1 subunit 1

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

NAE1 / APPBP1 (8)

Publications

No (8)

Tag

GST (1)

His (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human NAE1 / APPBP1 Protein (Recombinant His) - LS-G1576

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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NAE1 / APPBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121204

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.25 kDa

Price:

100 µg/$494

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NAE1 / APPBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117019

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.1 kDa

Price:

100 µg/$494

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Human NAE1 / APPBP1 Protein (Recombinant GST) (Full Length) - LS-G31386

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.48 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NAE1 / APPBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74492

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.25 kDa

Price:

20 µg/$150

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Human NAE1 / APPBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74493

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.1 kDa

Price:

20 µg/$150

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Human NAE1 / APPBP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64929

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.4 kDa

Price:

20 µg/$1,107

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Human NAE1 / APPBP1 Protein (Recombinant His-T7, N-terminus) (Thr229-Leu534) - LS-G133295

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

38.1kDa

Price:

10 µg/$265; 50 µg/$347; 200 µg/$682; 100 µg/$545; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866

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