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NAE1 / APPBP1
NEDD8 activating enzyme E1 subunit 1
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
| Gene Name: | NEDD8 activating enzyme E1 subunit 1 |
| Synonyms: | NAE1, A-116A10.1, APPBP1, HPP1, Proto-oncogene protein 1, APP-BP1, Ula-1, Protooncogene protein 1 |
| Target Sequences: | NM_003905 NP_003896.1 Q13564 |
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