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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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NAE1 / APPBP1

NEDD8 activating enzyme E1 subunit 1

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Gene Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: NAE1, A-116A10.1, APPBP1, HPP1, Proto-oncogene protein 1, APP-BP1, Ula-1, Protooncogene protein 1
Target Sequences: NM_003905 NP_003896.1 Q13564


NAE1 / APPBP1 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma reacted with anti-APPBP1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human NAE1 / APPBP1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
NAE1 / APPBP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-NAE1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI1E10] (IgG1) to Human NAE1 / APPBP1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
NAE1 / APPBP1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-NAE1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI1E10] (IgG1) to Human NAE1 / APPBP1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NAE1 / APPBP1 Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue at dilution 1:100
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $235.00; 100µl   $285.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
NAE1 / APPBP1 Antibody - Formalin-fixed and paraffin-embedded human testis tissue reacted with APPBP1 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human NAE1 / APPBP1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
NAE1 / APPBP1 Antibody - NAE1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human NAE1 / APPBP1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Human
ELISA, IP, WB
Unconjugated
100µg   $405.00
Select
Mouse Monoclonal [clone 4E8-H3] (IgG2a,k) to Human NAE1 / APPBP1
Human
ELISA, WB
Unconjugated
100µg   $560.00
Select
Rabbit Polyclonal to Human NAE1 / APPBP1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
NAE1 / APPBP1 Antibody - Western blot analysis of Human fetal muscle, kidney and liver tissue, using NAE1 Polyclonal Antibody at dilution of 1:500.
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Mouse, Rat, Human
ELISA, WB
Unconjugated
20µl   0.1mg/ml   $205.00; 60µl   0.1mg/ml   $235.00; 120µl   0.1mg/ml   $295.00; 200µl   0.1mg/ml   $395.00
NAE1 / APPBP1 Antibody - Western blot analysis of extracts of HepG2 cells using APPBP1 antibody. The lane on the left was treated with blocking peptide.
Select
Rabbit Polyclonal (IgG) to Human NAE1 / APPBP1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Viewing 1-25 of 56 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).