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NACC1 / NAC1

nucleus accumbens associated 1, BEN and BTB (POZ) domain containing

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

Gene Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: NACC1, BTBD30, BEN domain containing 8, NAC1, Transcriptional repressor NAC1, BEND8, BTBD14B, NAC-1
Target Sequences: NM_052876 NP_443108.1 Q96RE7

Publications (7)

1
A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Nakayama K, Nakayama N, Davidson B, Sheu JJ, Jinawath N, Santillan A, Salani R, Bristow RE, Morin PJ, Kurman RJ, Wang TL, Shih IeM. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:18739-44. [PubMed:17130457] [PMC:PMC1693732]
2
Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma. Shih IeM, Nakayama K, Wu G, Nakayama N, Zhang J, Wang TL. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011 24:638-45. (IHC; Human) [PubMed:21240255] [PMC:PMC3085564]
3
Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology. Wu PH, Hung SH, Ren T, Shih IeM, Tseng Y. Physical biology. 2011 8:15005. [PubMed:21301057] [PMC:PMC3164573]
4
Novel events in the molecular regulation of muscle mass in critically ill patients. Constantin D, McCullough J, Mahajan RP, Greenhaff PL. The Journal of physiology. 2011 589:3883-95. (WB; Human) [PubMed:21669975] [PMC:PMC3171892]
5
Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama N, Otsuki Y, Nakayama S, Miyazaki K. British journal of cancer. 2012 107:300-7. (WB; Human) [PubMed:22653145] [PMC:PMC3394978]
6
NAC1, a BTB/POZ protein overexpressed in uterine sarcomas. Rahman MT, Nakayama K, Ishikawa M, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Iida K, Yamada T, Miyazaki K. Anticancer research. 2012 32:3841-5. [PubMed:22993327]
7
Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Scofield MD, Korutla L, Jackson TG, Kalivas PW, Mackler SA. Neuroscience. 2012 227:44-54. (ICC; Rat) [PubMed:23022214] [PMC:PMC3505276]
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NACC1 / NAC1 (2)
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NACC1 / NAC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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NACC1 / NAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108122
HEK 293 Cells
Myc-DDK (Flag)
57.3 kDa
100 µg/$494
NACC1 / NAC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human NACC1 / NAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85022
293T Cells
Myc-DDK (Flag)
57.3 kDa
20 µg/$150
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