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Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Gene Name: | Myb-like, SWIRM and MPN domains 1 |
Synonyms: | MYSM1, 2A-DUB, 2ADUB, RP4-592A1.1, KIAA1915 |
Target Sequences: | Q5VVJ2 Q5VVJ2 |
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