MYPT2 / PPP1R12B

protein phosphatase 1, regulatory subunit 12B

Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

MYPT2 / PPP1R12B (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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MYPT2 / PPP1R12B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109081

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.1 kDa

Price:

100 µg/$494

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Human MYPT2 / PPP1R12B Protein (Recombinant GST) (Full Length) - LS-G29430

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MYPT2 / PPP1R12B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69705

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.1 kDa

Price:

20 µg/$1,107

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Human MYPT2 / PPP1R12B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85348

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.1 kDa

Price:

20 µg/$150

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