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MYO9B is a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | myosin IXB |
Synonyms: | MYO9B, CELIAC4, Myosin IXB, Myosin-IXb, Unconventional myosin-IXb, Unconventional myosin IXb, Unconventional myosin-9b, MYR5 |
Target Sequences: | NM_004145 NP_004136.2 Q13459 |
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