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MYO1E / Myosin IE
myosin IE
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
| Gene Name: | myosin IE |
| Synonyms: | MYO1E, FSGS6, HuncM-IC, MYO1E variant protein, Myosin IE, Myosin-IC, Unconventional myosin 1E, Unconventional myosin-Ie |
| Target Sequences: | NM_004998 NP_004989.2 Q12965 |
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