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MYO10 / Myosin-X
myosin X
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.
| Gene Name: | myosin X |
| Synonyms: | MYO10, Myosin X, Myosin-X, Unconventional myosin-10, Unconventional myosin-X, Unconventionnal myosin-X, KIAA0799 |
| Target Sequences: | NM_012334 NP_036466.2 Q9HD67 |
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