MYLK

myosin light chain kinase

Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca2+ entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

MYLK (9)

Publications

No (9)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

GST (2)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Chicken (1)

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (3)

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MYLK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108034

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.7 kDa

Price:

100 µg/$494

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Human MYLK Protein (Recombinant GST) (Full Length) - LS-G29422

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

136.6 kDa

Price:

2 µg/$439

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Human MYLK Protein (Recombinant GST) (Full Length) - LS-G29423

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MYLK Protein (Recombinant GST, N-terminus) (aa1710-1809) - LS-G59323

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Chicken MYLK Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa1435-1722) - LS-G56642

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human MYLK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66357

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.7 kDa

Price:

20 µg/$1,107

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Human MYLK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77541

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.7 kDa

Price:

20 µg/$150

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Human MYLK Protein (Recombinant His) (aa1661-1877) - LS-G13359

Source:

E. coli

Tag:

His

Molecular Weight:

26.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Mouse MYLK Protein (Recombinant His-T7) (aa1684-1884) - LS-G13361

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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