MYLIP / IDOL

Myosin Regulatory Light Chain Interacting Protein

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

MYLIP / IDOL (5)

Publications

No (5)

Tag

GST (2)

His (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

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Human MYLIP / IDOL Protein (Recombinant His) (Full Length) - LS-G23447

Source:

Yeast

Tag:

His

Molecular Weight:

51.9 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human MYLIP / IDOL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87007

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.7 kDa

Price:

20 µg/$150

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MYLIP / IDOL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114362

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.7 kDa

Price:

100 µg/$494

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Human MYLIP / IDOL Protein (Recombinant GST) (Full Length) - LS-G21882

Source:

E. coli

Tag:

GST

Molecular Weight:

77.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MYLIP / IDOL Protein (Recombinant GST) (Full Length) - LS-G33415

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74.69 kDa

Price:

10 µg/$479; 25 µg/$670

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