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MYL12A / MRCL3

Myosin, Light Chain 12A, Regulatory, Non-sarcomeric

MYL12A / MRCL3 is a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.

Gene Name:	Myosin, Light Chain 12A, Regulatory, Non-sarcomeric
Synonyms:	MYL12A, MRCL3, MLCB, MRLC3, MYL2B, MLC-2B
Target Sequences:	NM_006471 NP_006462.1 P19105

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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