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MYH7

myosin, heavy chain 7, cardiac muscle, beta

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Gene Name: myosin, heavy chain 7, cardiac muscle, beta
Synonyms: MYH7, Beta-myosin heavy chain, MYHCB, Myosin heavy chain (AA 1-96), MPD1, Myhc-slow, Myopathy, distal 1, Myosin heavy chain 7, MyHC-beta, Myosin-7, CMD1S, CMH1, SPMD, SPMM
Target Sequences: M58018 P12883 P12883

Publications (3)

1
Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes. Christian Zuppinger, George Gibbons, Priyanka Dutta-Passecker, Adrian Segiser, Henriette Most, Thomas M Suter. European journal of histochemistry : EJH. 2017 Jun;61:2763. [Full Text Article] [PubMed:28735524] [PMC:PMC5484009] Related Antibodies: LS-C312448.
2
3D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids. Philippe Beauchamp, Christopher B Jackson, Lijo Cherian Ozhathil, Irina Agarkova, Cristi L Galindo, Douglas B Sawyer, Thomas M Suter, Christian Zuppinger. Frontiers in molecular biosciences. 2020 Feb;7:14. [Full Text Article] [PubMed:32118040] [PMC:PMC7033479] Related Antibodies: LS-C312448.
3
Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction. Mouton J, Loos B, Moolman-Smook JC, Kinnear CJ. Experimental cell research. Feb;331:338-51. [Full Text Article] [PubMed:25449695] Related Antibodies: LS-B5888.

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Proteins (2)
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MYH7 (2)
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GST, N-terminus (1)
His (1)
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Wheat Germ Extract (1)
MYH7 Protein - Recombinant Myosin Heavy Chain 7, Cardiac Muscle, Beta By SDS-PAGE
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E. coli
His
30.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
MYH7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).