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Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Gene Name: | MAX dimerization protein 4 |
Synonyms: | MXD4, BHLHc12, MAX dimerization protein 4, MAD4, Max dimerizer 4, Max-associated protein 4, MST149, Mad4 homolog, MSTP149 |
Target Sequences: | NM_006454 NP_006445.1 Q14582 |
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