MUSK

muscle, skeletal, receptor tyrosine kinase

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

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Products

Proteins (7)

Type

Recombinant (7)

Target

MUSK (7)

Publications

No (7)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

DDK (Flag)-His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-GST (1)

Species

Human (5)

Mouse (2)

Source

Baculovirus (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human MUSK Protein (Recombinant 6His, N-terminus) (aa24-495) - LS-G23046

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

54.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human MUSK Protein (Recombinant GST) (aa24-495) - LS-G20991

Source:

E. coli

Tag:

GST

Molecular Weight:

79.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse MUSK Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa22-494) - LS-G56773

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human MUSK Protein (Recombinant GST, N-terminus) (aa301-400) - LS-G59299

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MUSK Protein (Recombinant His-GST) (Arg433-Val783) - LS-G97710

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68 kDa

Price:

50 µg/$707

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Mouse MUSK Protein (Recombinant His) (aa517-777) - LS-G15450

Source:

E. coli

Tag:

His

Molecular Weight:

31.1 kDa

Price:

10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219

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Human MUSK Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142231

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

55 kDa

Price:

20 µg/$1,107

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