MUSK

muscle, skeletal, receptor tyrosine kinase

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

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Products

Antibodies (42)

ELISA Kits (16)

Proteins (7)

Type

Custom (3)

Primary (42)

Recombinant (7)

Sandwich (11)

Sandwich CLIA (2)

Target

MUSK (65)

Reactivity

Human (47)

Mouse (21)

Rat (12)

Chicken (2)

Chimpanzee (3)

Gibbon (3)

Guinea pig (3)

Monkey (4)

Porcine (1)

Rabbit (4)

Application

IHC (22)

IHC-P (6)

WB (37)

Flo (9)

ELISA (23)

ICC (1)

IF (4)

IP (1)

Peptide-ELISA (1)

Host

rabbit (36)

mouse (5)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (19)

IgG1 (3)

IgG1,k (1)

IgG2b,k (1)

Clonality

monoclonal mc (5)

polyclonal pc (37)

Clone

10A4 (2)

1429CT456.173.44 (1)

2H6 (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (1)

96-Well Strip Plate (13)

APC (1)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Preservative Free (1)

Unconjugated (22)

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Epitope

aa517-777 (8)

aa35-65 (7)

aa829-859 (7)

aa163-212 (4)

C-Terminus (2)

690-770 aa (1)

Amino Acid: 24-209 (1)

Extracellular Domain (1)

N-Terminus (1)

aa70-366 (1)

Publications

No (65)

Sample Type

Cell Lysates (1)

Plasma (7)

Serum (7)

Tissue Homogenates (4)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

DDK (Flag)-His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-GST (1)

Species

Human (5)

Mouse (2)

Source

Baculovirus (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

MUSK Antibody (aa517-777) LS-B15263

Antibody:

MUSK Rabbit anti-Mouse Polyclonal (aa517-777) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$460

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MUSK Antibody (clone 1429CT456.173.44) LS-C356259

Antibody:

MUSK Mouse anti-Mouse Monoclonal (1429CT456.173.44) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

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MUSK Antibody (aa70-366) LS-C99098

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa70-366) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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MUSK Antibody (C-Terminus) LS-C47086

Antibody:

MUSK Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$379

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MUSK Antibody (N-Terminus) LS-C46832

Antibody:

MUSK Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$379

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Human MUSK Protein (Recombinant 6His, N-terminus) (aa24-495) - LS-G23046

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

54.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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MUSK Antibody (aa517-777, PE) LS-C727048

Antibody:

MUSK Rabbit anti-Mouse Polyclonal (aa517-777) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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MUSK Antibody (aa35-65) LS-C99096

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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MUSK Antibody (clone 2H6) LS-C133332

Antibody:

MUSK Mouse anti-Human Monoclonal (2H6) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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MUSK Antibody (aa829-859) LS-C99097

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa829-859) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

MUSK Antibody (clone 10A4) LS-C108753

Antibody:

MUSK Mouse anti-Human Monoclonal (10A4) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µl/$435

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MUSK Antibody (aa163-212) LS-C146062

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa163-212) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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MUSK Antibody (aa163-212, HRP) LS-C470528

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa163-212) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP

• Unconjugated
• HRP

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MUSK Antibody (Amino Acid: 24-209, clone 10A4) LS-C758775

Antibody:

MUSK Mouse anti-Human Monoclonal (Amino Acid: 24-209) (10A4) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated

Price:

100 µl/$541

Select

MUSK Antibody (690-770 aa) LS-C381102

Antibody:

MUSK Rabbit anti-Human Polyclonal (690-770 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MUSK Antibody (Extracellular Domain) LS-C37402

Antibody:

MUSK Goat anti-Human Polyclonal (Extracellular Domain) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$951

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MUSK Antibody (aa35-65) LS-C323168

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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MUSK Antibody (aa35-65, Biotin) LS-C263755

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

MUSK Antibody (aa35-65, FITC) LS-C263757

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

MUSK Antibody (aa35-65, PE) LS-C263759

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

MUSK Antibody (aa35-65, Azide-free, HRP) LS-C263758

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

MUSK Antibody (aa35-65, APC) LS-C263756

Antibody:

MUSK Rabbit anti-Human Polyclonal (aa35-65) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• HRP, Azide-free
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • HRP, Azide-free
  • APC

Select

Human MUSK Protein (Recombinant GST) (aa24-495) - LS-G20991

Source:

E. coli

Tag:

GST

Molecular Weight:

79.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human MUSK (Sandwich ELISA) ELISA Kit - LS-F13338

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Human MUSK (Sandwich ELISA) ELISA Kit - LS-F6766

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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