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20700 44th Avenue W
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MURF1 / IRF
tripartite motif containing 63, E3 ubiquitin protein ligase
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
| Gene Name: | tripartite motif containing 63, E3 ubiquitin protein ligase |
| Family/Subfamily: | Tripartite Motif |
| Synonyms: | TRIM63, Iris RING finger protein, MURF-1, MURF1, MuRF2, IRF, RING finger protein 28, RNF28, Tripartite motif-containing 63, Tripartite motif containing 63, SMRZ |
| Target Sequences: | NM_032588 NP_115977.2 Q969Q1 |
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