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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MUL1 / MULAN

mitochondrial E3 ubiquitin protein ligase 1

Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Gene Name: mitochondrial E3 ubiquitin protein ligase 1
Synonyms: MUL1, C1orf166, E3 SUMO-protein ligase MUL1, E3 ubiquitin ligase, MULAN, RING finger protein 218, MAPL, RNF218, GIDE, RP11-401M16.2
Target Sequences: NM_024544 NP_078820.2 Q969V5

Filtered By: None
Target
MUL1 / MULAN (20)
Reactivity
Human (20)
Mouse (5)
Rat (1)
Bat (4)
Bovine (4)
Chimpanzee (6)
Dog (8)
Gibbon (3)
Guinea pig (8)
Horse (8)
Monkey (8)
Rabbit (8)
Application
IHC (2)
WB (20)
ELISA (8)
IF (1)
Host
rabbit (20)
Isotype
IgG (14)
Clonality
polyclonal pc (20)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (8)
Epitope
aa272-301 (8)
aa143-192 (4)
aa216-265 (4)
aa176-210 (1)
Publications
No (20)
Showing 1-20 of 20 results

MUL1 / MULAN Antibody (aa272-301) LS-C329860
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
Unconjugated
200µl  $530.00

MUL1 / MULAN Antibody (aa272-301, Biotin) LS-C208973
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

MUL1 / MULAN Antibody (aa272-301, FITC) LS-C207279
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
FITC Conjugated
200µl 0.45mg/ml  $680.00

MUL1 / MULAN Antibody (aa272-301, PE) LS-C207281
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
PE Conjugated
200µl  $680.00

MUL1 / MULAN Antibody (aa272-301, Azide-free, HRP) LS-C207280
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

MUL1 / MULAN Antibody (aa272-301, APC) LS-C208972
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
APC Conjugated
200µl  $680.00

MUL1 / MULAN Antibody (aa272-301, AP) LS-C208971
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA WB
AP Conjugated
200µl  $680.00

MUL1 / MULAN Antibody (aa272-301) LS-C164681
Rabbit Polyclonal to Human MUL1 / MULAN
Human
WB
Unconjugated
400µl  $305.00
MUL1 Antibody western blot of human placenta tissue lysates (35 ug/lane). The MUL1 antibody detected the MUL1 protein (arrow).
MUL1 Antibody western blot of human placenta tissue lysates (35 ug/lane). The MUL1 antibody detected the MUL1 protein (arrow).

MUL1 / MULAN Antibody LS-C748186
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00
Immunohistochemistry of paraffin-embedded human tonsil using MUL1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using MUL1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using MUL1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using MUL1 antibody at dilution of 1:100 (40x lens).

MUL1 / MULAN Antibody LS-C753740
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
ELISA IHC WB
Unconjugated
100µg  $335.00

MUL1 / MULAN Antibody LS-C410698
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Human
WB
Unconjugated
100µl  $295.00; 200µl  $385.00

MUL1 / MULAN Antibody (aa216-265) LS-C102020
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa216-265, HRP) LS-C444969
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa216-265, Biotin) LS-C444967
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa216-265, FITC) LS-C444968
Rabbit Polyclonal (IgG) to Human MUL1 / MULAN
Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa143-192) LS-C110775
Rabbit Polyclonal to Human MUL1 / MULAN
Rabbit, Mouse, Dog, Guinea pig, Horse, Human, Monkey
WB
Unconjugated
50µg  $365.00
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa143-192, HRP) LS-C444966
Rabbit Polyclonal to Human MUL1 / MULAN
Rabbit, Mouse, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa143-192, Biotin) LS-C444964
Rabbit Polyclonal to Human MUL1 / MULAN
Rabbit, Mouse, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa143-192, FITC) LS-C444965
Rabbit Polyclonal to Human MUL1 / MULAN
Rabbit, Mouse, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
MUL1 / C1orf166 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MUL1 / MULAN Antibody (aa176-210) LS-C344409
Rabbit Polyclonal to Human MUL1 / MULAN
Human
WB
Unconjugated
400µl  $305.00
Western blot of lysate from A431 cell line with MUL1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35 ug.
Western blot of lysate from A431 cell line with MUL1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35 ug.
Showing 1-20 of 20 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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