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MUC5AC

mucin 5AC, oligomeric mucus/gel-forming

MUC5AC has been isolated from airway secretions. It is found in the protective film of mucus coating the mucosal surfaces of the respiratory tract and the normal gastrointestinal tissues. Mucins are also expressed at low levels in human fetal gut. MUC5AC is involved in epithelial cell proliferation and differentiation in adult airway mucosa and can be used as a marker for hypersecretory disorders. MUC5AC has also been observed in various tumors. For instance it is expressed in primary mucinous ovarian tumors but not in colonic carcinoma metastatic to the ovary, which makes it a useful marker to distinguish the two types of cancer.

Gene Name: mucin 5AC, oligomeric mucus/gel-forming
Synonyms: MUC5AC, Gastric mucin, Major airway glycoprotein, Muc5/5ac, Mucin-5AC, LeB, Lewis B blood group antigen, Tracheobronchial mucin, TBM, MUC-5AC, MUC5
Target Sequences: AJ001403 CAA04738.1 P98088

Publications (6)

1
A beneficiary role for neuraminidase in influenza virus penetration through the respiratory mucus. Yang X, Steukers L, Forier K, Xiong R, Braeckmans K, Van Reeth K, Nauwynck H. PloS one. 2014 9:e110026. (IHC-P; Human) [Full Text Article] [PubMed:25333824] [PMC:PMC4198190]
2
Limbal niche cells: a novel feeder cell for autologous cultivated oral mucosal epithelial transplantation. Duan CY, Xie HT, Zhao XY, Zhang MC. Regenerative medicine. 2019 January;14:49-62. [Full Text Article] [PubMed:30572808] Related Antibodies: LS-C390690.
3
Vagal sensory neurons drive mucous cell metaplasia. Sébastien Talbot, Benjamin Doyle, Junwei Huang, Jo-Chiao Wang, Maryam Ahmadi, David P Roberson, Ajay Yekkirala, Simmie L Foster, Liam E Browne, Bruce P Bean, Bruce D Levy, Clifford J Woolf. The Journal of allergy and clinical immunology. 2020 June;145:1693-1696.e4. [Full Text Article] [PubMed:31954778]
4
Reduced allergic lung inflammation and airway responsiveness in mice lacking the cytoskeletal protein gelsolin. Maya Mikami, Gene T Yocum, Nicola M Heller, Charles W Emala. American journal of physiology. Lung cellular and molecular physiology. 2020 September; [Full Text Article] [PubMed:32902333] [PMC:PMC7789977]
5
Analysis of mucosal mucins separated by SDS-urea agarose polyacrylamide composite gel electrophoresis. Samah M A Issa, Benjamin L Schulz, Nicolle H Packer, Niclas G Karlsson. Electrophoresis. 2011 December;32:3554-63. [Full Text Article] [PubMed:22120911] Related Antibodies: LS-B2434.
6
Vegetable glycerin e-cigarette aerosols cause airway inflammation and ion channel dysfunction. Michael D Kim, Samuel Chung, John S Dennis, Makoto Yoshida, Carolina Aguiar, Sheyla P Aller, Eliana S Mendes, Andreas Schmid, Juan Sabater, Nathalie Baumlin, Matthias Salathe. Frontiers in pharmacology. 2022 October;13:1012723. [Full Text Article] [PubMed:36225570] [PMC:PMC9549247]
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Proteins (9)
Recombinant (9)
MUC5AC (9)
No (9)
GST, N-terminus (1)
His (4)
His-GST (1)
His-S (1)
His-T7 (2)
Human (3)
Mouse (4)
Rat (2)
E. coli (8)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (1)
MUC5AC Protein
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E. coli
His-S
15.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
MUC5AC Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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E. coli
His
33.7 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
MUC5AC Protein - Recombinant  Mucin 5 Subtype AC By SDS-PAGE
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E. coli
His-T7
14.1 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
MUC5AC Protein - Recombinant  Mucin 5 Subtype AC By SDS-PAGE
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E. coli
His-T7
17.4 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,948; 500 µg/$1,493; 5 mg/$3,401
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E. coli
215 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
23.76 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
MUC5AC Protein - Recombinant Mucin 5 Subtype AC By SDS-PAGE
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E. coli
His
14.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Select
E. coli
His
14.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
MUC5AC Protein - Recombinant Mucin 5 Subtype AC By SDS-PAGE
Select
E. coli
His-GST
44.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).