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MtTFA / TFAM

transcription factor A, mitochondrial

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.

Gene Name: transcription factor A, mitochondrial
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: TFAM, MTTF1, TCF-6, TCF6, TCF6L1, Transcription factor 6-like 2, Transcription factor 6-like 3, TCF6L2, TCF6L3, Transcription factor 6, Transcription factor 6-like 1, MTTFA
Target Sequences: NM_003201 NP_003192.1 Q00059

Publications (7)

1
PGC-1 overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion. Morris EM, Meers GM, Booth FW, Fritsche KL, Hardin CD, Thyfault JP, Ibdah JA. American journal of physiology. Gastrointestinal and liver physiology. 2012 303:G979-92. (WB; Rat) [PubMed:22899824] [PMC:PMC3469696]
2
Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis. Ohashi N, Morino K, Ida S, Sekine O, Lemecha M, Kume S, Park SY, Choi CS, Ugi S, Maegawa H. Diabetes. 2017 September;66:2351-2362. [Full Text Article] [PubMed:28637651] Related Antibodies: LS-C30495.
3
MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-a signalling in beige adipocytes. Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, Sato D, Sekine O, Ugi S, Maegawa H. Scientific reports. 2018 October;8:15096. [Full Text Article] [PubMed:30305668] [PMC:PMC6180067] Related Antibodies: LS-C30495.
4
Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function. Stauch KL, Purnell PR, Fox HS. Aging. 2014 Apr;6:320-34. [Full Text Article] [PubMed:24827396] [PMC:PMC4032798] Related Antibodies: LS-C30495.
5
Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability. Stauch KL, Purnell PR, Fox HS. Journal of proteome research. 2014 May;13:2620-36. [Full Text Article] [PubMed:24708184] [PMC:PMC4015687] Related Antibodies: LS-C30495.
6
MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3. Yamamoto H, Morino K, Nishio Y, Ugi S, Yoshizaki T, Kashiwagi A, Maegawa H. American journal of physiology. Endocrinology and metabolism. 2012 Dec;303:E1419-27. [Full Text Article] [PubMed:23047984] Related Antibodies: LS-C30495.
7
Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism. Purnell PR, Villeneuve LM, Fox HS. Proteomics. Dec; [Full Text Article] [PubMed:25546256] Related Antibodies: LS-C30495.
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ELISA Kits (3)
Sandwich (3)
MtTFA / TFAM (3)
Human (1)
Mouse (2)
96-Well Strip Plate (3)
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Cell Lysates (1)
Plasma (1)
Serum (1)
Tissue Homogenates (2)
MtTFA / TFAM ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
MtTFA / TFAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MtTFA / TFAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$854
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).