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MTPAP

mitochondrial poly(A) polymerase

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.

Gene Name:	mitochondrial poly(A) polymerase
Synonyms:	MTPAP, PAP, Terminal uridylyltransferase 1, PAPD1, TUTase 1, RP11-305E6.3, SPAX4
Target Sequences:	NM_018109 NP_060579.3 Q9NVV4

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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