MTM1 / Myotubularin

myotubularin 1

Myotubularin (MTM1), a myotubularin-related phosphatase, has been shown to contain the consensus active site of dual specificity protein phosphatases (DSPs) and to share inhibition and inactivation characteristics with other DSPs in vitro and in vivo. MTM1 also has been shown to possess a SET-interacting domain (SID) which is unique to myotubularin-related proteins. SID has been shown to mediate interactions in vitro with SET (Suvar3-9, Enhancer of zeste, trithorax) domains in nuclear proteins implicated in chromatin organization. Recent studies have indicated that MTM1 is also a lipid phosphatase, acting on phosphatidylinositol 3-monophosphate, and may regulate the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Additionally, myotubularin has been implicated in the regulation of cell growth and the release of spermatids. MTM1 has been identified as the locus containing mutations responsible for X-linked myotubular myopathy (XLMTM), and more than 130 different mutations have been identified in the MTM1 gene worldwide.

☰ Filters

Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

MTM1 / Myotubularin (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

Human MTM1 / Myotubularin Protein (Recombinant GST) (Full Length) - LS-G29398

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

96.3 kDa

Price:

2 µg/$439

Select

Human MTM1 / Myotubularin Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59289

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human MTM1 / Myotubularin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77548

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.8 kDa

Price:

20 µg/$150

Select

MTM1 / Myotubularin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98982

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.8 kDa

Price:

100 µg/$494

Viewing 1-4 of 4 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.