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MTHFR

methylenetetrahydrofolate reductase (NAD(P)H)

MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Gene Name:	methylenetetrahydrofolate reductase (NAD(P)H)
Synonyms:	MTHFR
Target Sequences:	NM_005957 NP_005948.3 P42898

Publications (1)

Oxidative stress inhibits distant metastasis by human melanoma cells. Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Nature. 2015 527:186-91. (IHC, WB; Human) [Full Text Article] [PubMed:26466563] [PMC:PMC4644103] Related Antibodies: LS-C157974.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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