MTBP / Mdm2-Binding Protein

Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by post translational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

MTBP / Mdm2-Binding Protein (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human MTBP / Mdm2-Binding Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86285

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

102 kDa

Price:

20 µg/$150

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MTBP / Mdm2-Binding Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110510

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

102 kDa

Price:

100 µg/$494

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