MTBP / Mdm2-Binding Protein

Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by post translational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

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Products

ELISA Kits (3)

Type

Custom (2)

Sandwich (1)

Target

MTBP / Mdm2-Binding Protein (3)

Reactivity

Human (2)

Mouse (1)

Format

96-Well Strip Plate (3)

Publications

No (3)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Mouse MTBP / Mdm2-Binding Protein (Custom ELISA) ELISA Kit - LS-F16246

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human MTBP / Mdm2-Binding Protein (Custom ELISA) ELISA Kit - LS-F16245

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human MTBP / Mdm2-Binding Protein (Sandwich ELISA) ELISA Kit - LS-F33889

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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