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MSR1 / CD204

macrophage scavenger receptor 1

MSR1 / CD204 is a member of the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gene Name: macrophage scavenger receptor 1
Synonyms: MSR1, CD204 antigen, SCARA1, PhSR1, SR-A, CD204, PhSR2, SRA, MSR2
Target Sequences: NM_002445 NP_002436.1 P21757

Publications (3)

1
Age-associated and therapy-induced alterations in the cellular microenvironment of experimental gliomas. Schneider H, Lohmann B, Wirsching HG, Hasenbach K, Rushing EJ, Frei K, Pruschy M, Tabatabai G, Weller M. Oncotarget. 2017 August;8:87124-87135. (Mouse) [Full Text Article] [PubMed:29152068] [PMC:PMC5675620]
2
Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner. Xu J, Yu Y, He X, Niu N, Li X, Zhang R, Hu J, Ma J, Yu X, Sun Y, Ni H, Wang F. American journal of translational research. 2019 September;11:6040-6054. [Full Text Article] [PubMed:31632572] [PMC:PMC6789263] Related Antibodies: LS-C336674.
3
The phosphodiesterase 4 inhibitor AA6216 suppresses activity of fibrosis-specific macrophages. Takashi Matsuhira , Osamu Nishiyama, Yuji Tabata, Shinji Kurashimo, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda. Biochemistry and biophysics reports. 2021 Aug;28:101118. [Full Text Article] [PubMed:34485715] [PMC:PMC8408426] Related Antibodies: LS-C43466.

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ELISA Kits (16)
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MSR1 / CD204 (16)
Human (7)
Mouse (2)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (13)
No (16)
Cell Lysates (2)
Plasma (5)
Serum (5)
Tissue Homogenates (4)
MSR1 / CD204 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MSR1 / CD204 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
MSR1 / CD204 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
MSR1 / CD204 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
MSR1 / CD204 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
MSR1 / CD204 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
27.43 - 20000 pg/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$968
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
MSR1 / CD204 ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$877
MSR1 / CD204 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).