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Unfortunately, the antibody (ID:140164) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



MSH6

mutS homolog 6

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.

Gene Name: mutS homolog 6
Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit
Target Sequences: NM_000179 NP_000170.1 P52701

Filtered By: None
Target
msh6 (42)
Reactivity
Human (42)
Mouse (13)
Rat (4)
Bat (1)
Dog (1)
Gibbon (3)
Guinea pig (4)
Monkey (8)
Application
IHC (8)
IHC-Fr (2)
IHC-P (15)
WB (24)
Flo (1)
ELISA (19)
GS (2)
ICC (2)
IF (10)
IP (3)
PLA (2)
Host
rabbit (23)
mouse (16)
goat (3)
Isotype
IgG (15)
IgG1 (13)
IgG1,k (2)
Clonality
monoclonal mc (18)
polyclonal pc (24)
Clone
15B (1)
1F2 (1)
3A10H7 (1)
3E1 (1)
44 (3)
5B11 (1)
SP93 (1)
SPM525 (1)
Format
AP Conjugated (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Ready-to-Use (1)
Unconjugated (31)
Epitope
Internal (5)
aa1-400 (4)
aa251-300 (4)
C-Terminus (2)
aa350-400 (2)
Glu371 (1)
aa2-14 (1)
aa217-395 (1)
aa310-390 (1)
aa341-390 (1)
Publications
No (42)
Showing 1-25 out of 42 results
Anti-MSH6 Antibody (aa217-395, clone 5B11) IHC-plus™ LS-B10739

Mouse Monoclonal [clone 5B11] (IgG1) to Human MSH6
Human
ELISA IHC-P WB
Unconjugated
Anti-MSH6 Antibody (Internal, clone SP93) LS-C210345

Rabbit Monoclonal [clone SP93] (IgG) to Human MSH6
Human
IHC-P WB
Unconjugated
Anti-MSH6 Antibody (clone 3E1) LS-C169448

Mouse Monoclonal [clone 3E1] (IgG1) to Human MSH6
Human
ELISA Flo ICC IF IHC-P WB
Unconjugated
Anti-MSH6 Antibody (C-Terminus) LS-C191051

Rabbit Monoclonal (IgG) to Human MSH6
Human, Monkey
IF WB
Unconjugated
Anti-MSH6 Antibody (Internal) LS-C352291

Rabbit Polyclonal to Human MSH6
Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-MSH6 Antibody LS-C331182

Rabbit Polyclonal (IgG) to Human MSH6
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-MSH6 Antibody (aa310-390) LS-C383879

Rabbit Polyclonal (IgG) to Human MSH6
Mouse, Human, Monkey
ELISA IF IHC WB
Unconjugated
Anti-MSH6 Antibody LS-C332402

Rabbit Polyclonal (IgG) to Human MSH6
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-MSH6 Antibody (clone 1F2) LS-C197374

Mouse Monoclonal [clone 1F2] (IgG1,k) to Human MSH6
Human
ELISA IF WB
Unconjugated
Anti-MSH6 Antibody (aa2-14) IHC-plus™ LS-B5106

Goat Polyclonal to Human MSH6
Mouse, Rat, Bat, Human, Monkey
IHC-P
Unconjugated
Anti-MSH6 Antibody (aa350-400) LS-C286964

Goat Polyclonal (IgG) to Human MSH6
Human
IF IHC-P IP PLA WB
Unconjugated
Anti-MSH6 Antibody LS-C400893

Rabbit Polyclonal (IgG) to Human MSH6
Mouse, Human
ELISA IHC WB
Unconjugated
Anti-MSH6 Antibody LS-C43815

Mouse Monoclonal (IgG1) to Human MSH6
Human
ELISA GS WB
Unconjugated
Anti-MSH6 Antibody (Glu371) LS-C176981

Rabbit Polyclonal to Human MSH6
Mouse, Human
IF IHC-P WB
Unconjugated
Anti-MSH6 Antibody (clone 3A10H7) LS-C109105

Mouse Monoclonal [clone 3A10H7] (IgG1) to Human MSH6
Human
ELISA WB
Unconjugated
Anti-MSH6 Antibody (aa1-400, HRP) LS-C370002

Rabbit Polyclonal (IgG) to Human MSH6
Human
ELISA IHC IHC-P
HRP Conjugated
Anti-MSH6 Antibody (aa1-400, Biotin) LS-C370005

Rabbit Polyclonal (IgG) to Human MSH6
Human
ELISA IHC IHC-P
Biotin Conjugated
Anti-MSH6 Antibody (aa1-400, FITC) LS-C370001

Rabbit Polyclonal (IgG) to Human MSH6
Human
ELISA IHC IHC-P
FITC Conjugated
Anti-MSH6 Antibody LS-C9101

Mouse Monoclonal (IgG1) to Human MSH6
Human
ELISA GS
Unconjugated
Anti-MSH6 Antibody (Internal, clone 15B) LS-C191748

Rabbit Polyclonal [clone 15B] (IgG) to Human MSH6
Mouse, Human
ELISA WB
Unconjugated
Anti-MSH6 Antibody (clone 44) LS-C95606

Mouse Monoclonal [clone 44] (IgG1) to Human MSH6
Mouse, Dog, Rat, Human
IP WB
Unconjugated
Anti-MSH6 Antibody (aa341-390) LS-C119578

Rabbit Polyclonal (IgG) to Human MSH6
Mouse, Human
ELISA WB
Unconjugated
Anti-MSH6 Antibody (aa350-400) LS-C286390

Goat Polyclonal (IgG) to Human MSH6
Human
IF IHC-P
Unconjugated
Anti-MSH6 Antibody (C-Terminus) LS-C286965

Rabbit Polyclonal (IgG) to Human MSH6
Human
IP PLA WB
Unconjugated
Anti-MSH6 Antibody (clone 44, Ready-to-Use) LS-C348526

Mouse Monoclonal [clone 44] (IgG1) to Human MSH6
Human
IHC-Fr IHC-P
Unconjugated, Ready-to-Use

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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