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MSH2

mutS homolog 2

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

Gene Name: mutS homolog 2
Synonyms: MSH2, COCA1, FCC1, HNPCC, HNPCC1, MutS protein homolog 2, HMSH2, LCFS2
Target Sequences: NM_000251 NP_000242.1 P43246

☰ Filters
Antibodies (62)
ELISA Kits (6)
Proteins (6)
Custom (3)
Over-Expression Lysate (2)
Primary (62)
Recombinant (4)
Sandwich (2)
Sandwich CLIA (1)
MSH2 (74)
Human (64)
Mouse (16)
Rat (20)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (6)
Dog (1)
Gibbon (6)
Guinea pig (4)
Hamster (8)
Horse (4)
Monkey (11)
Orangutan (6)
Pig (4)
Rabbit (4)
Xenopus (4)
Zebrafish (8)
IHC (25)
IHC-Fr (5)
IHC-P (16)
WB (41)
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ELISA (17)
ICC (10)
IF (17)
IP (8)
Peptide-ELISA (2)
rabbit (39)
mouse (22)
sheep (1)
Product Group
IHCPlus (1)
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PathPlus Cancer Pathology (1)
IgG (32)
IgG1 (5)
IgG1,k (4)
IgG2a (1)
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IgG2b (7)
monoclonal mc (22)
polyclonal pc (38)
recombinant monoclonal rmc (2)
1184CT1.3.2 (1)
25D12 (2)
2G9 (1)
AHC0174 (1)
G219-1129 (1)
G410.1 (1)
RBT-MSH2 (2)
UMAB259 (2)
96-Well Strip Plate (6)
AP Conjugated (1)
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Azide-free (1)
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aa637-665 (8)
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MSH2 Antibody - Immunohistochemical analysis of MSH2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MSH2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MSH2 Antibody - IHC of MSH2 on FFPE Colon Carcinoma tissue.
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MSH2 Rabbit anti-Human Recombinant Monoclonal (RBT-MSH2) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$349
MSH2 Antibody - Anti-MSH2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MSH2 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
MSH2 Antibody - Immunohistochemistry of paraffin-embedded human kidney cancer using MSH2 antibody at dilution of 1:200 (x400 lens).
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MSH2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$263; 50 µl/$301; 100 µl/$359; 200 µl/$473
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MSH2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
MSH2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
MSH2 Mouse anti-Human Monoclonal (Concentrated) Antibody
Human
ELISA, IHC-P
Unconjugated, Concentrated
0.05 ml/$460
MSH2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Breast cancer (left) and lung cancer (right) tissues, showing nuclear localization with DAB staining using MSH2 Monoclonal Antibody.
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MSH2 Mouse anti-Human Monoclonal Antibody
Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100 µl/$393
MSH2 Antibody - MSH2 antibody IHC-paraffin: Mouse Intestine Tissue.
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MSH2 Rabbit anti-Human Polyclonal (aa337-583) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$431
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
200 µl/$652
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, WB
Biotin Conjugated
200 µl/$863
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, WB
FITC Conjugated
200 µl/$863
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) (APC) Antibody
Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200 µl/$863
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) (AP) Antibody
Human
ELISA, Flo, ICC, IF, WB
AP Conjugated
200 µl/$863
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) (PE) Antibody
Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200 µl/$863
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$863
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MSH2 Mouse anti-Human Monoclonal Antibody
Human, Monkey
ICC, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$361; 100 µl/$421; 200 µl/$481
MSH2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MSH2 Antibody. The picture on the right is blocked with the synthesized peptide.
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MSH2 Rabbit anti-Human Polyclonal (aa541-590) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$328; 100 µl/$388
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MSH2 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$970
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MSH2 Mouse anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$657
MSH2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
MSH2 Protein - 12.5% SDS-PAGE of human MSH2 stained with Coomassie Blue
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Wheat Germ Extract
GST
131.1 kDa
10 µg/$479; 25 µg/$670
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MSH2 Rabbit anti-Human Polyclonal (510-590 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µl/$289; 100 µl/$319; 200 µl/$389
MSH2 Antibody - Detection of Human and Mouse MSH2 by Immunohistochemistry. Sample: FFPE section of human metastatic lymph node (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-MSH2 used at a dilution of 1:1000 (1and 1:5000 (0.2 Detection: DAB.
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MSH2 Rabbit anti-Human Polyclonal (aa875-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$493
MSH2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using MSH2 antibody.
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MSH2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
MSH2 Antibody - MSH2 Antibody western blot of SW480,U251 cell line lysates (35 ug/lane). The MSH2 antibody detected the MSH2 protein (arrow).
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MSH2 Rabbit anti-Human Polyclonal (aa637-665) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$391
Viewing 1-25 of 74 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).