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MRVI1
Murine Retrovirus Integration Site 1 Homolog
MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
| Gene Name: | Murine Retrovirus Integration Site 1 Homolog |
| Synonyms: | MRVI1, IRAG, JAW1-related protein MRVI1, JAW1L, Protein MRVI1 |
| Target Sequences: | NM_006069 NP_569056.4 Q9Y6F6 |
Publications (1)
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