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MRNP41 / RAE1
ribonucleic acid export 1
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
| Gene Name: | ribonucleic acid export 1 |
| Synonyms: | RAE1, DJ481F12.3, DJ800J21.1, Mnrp41, MRNA export factor, MRNA-binding protein, 41-kD, Rae1 protein homolog, MIG14, Migration-inducing gene 14, MRNA export protein, MRNP41 |
| Target Sequences: | NM_003610 NP_003601.1 P78406 |
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