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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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MPRIP / RIP3
myosin phosphatase Rho interacting protein
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
| Gene Name: | myosin phosphatase Rho interacting protein |
| Synonyms: | MPRIP, KIAA0864, M-RIP, p116Rip, Rho interacting protein 3, RHOIP3, RIP3, MRIP, Rho-interacting protein 3 |
| Target Sequences: | AA675912 Q6WCQ1 Q6WCQ1 |
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