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MORF / MYST4
K(lysine) acetyltransferase 6B
MORF / MYST4 is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | K(lysine) acetyltransferase 6B |
| Synonyms: | KAT6B, Histone acetyltransferase MOZ2, Histone acetyltransferase MORF, KIAA0383, MOZ2, MYST-4, K(lysine) acetyltransferase 6B, Querkopf, MORF, MOZ-related factor, ZC2HC6B, GTPTS, MYST4, Qkf |
| Target Sequences: | NM_012330 NP_036462.2 Q8WYB5 |
Publications (1)
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