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MNAT1
MNAT CDK-activating kinase assembly factor 1
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
| Gene Name: | MNAT CDK-activating kinase assembly factor 1 |
| Synonyms: | MNAT1, Cyclin G1 interacting protein, Cyclin-G1-interacting protein, MAT1, p35, p36, RING finger protein 66, RING finger protein MAT1, Menage a trois, RNF66, TFB3, CAP35, CDK7/cyclin-H assembly factor |
| Target Sequences: | NM_002431 NP_002422.1 P51948 |
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