MMS21 / NSMCE2

non-SMC element 2, MMS21 homolog (S. cerevisiae)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

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Products

Antibodies (23)

Type

Primary (23)

Target

MMS21 / NSMCE2 (23)

Reactivity

Human (23)

Mouse (1)

Rat (1)

Bovine (3)

Chimpanzee (3)

Gibbon (3)

Horse (3)

Pig (3)

Rabbit (3)

Application

IHC (4)

IHC-P (4)

WB (17)

Flo (8)

ELISA (6)

IF (9)

IP (3)

Peptide-ELISA (1)

Host

rabbit (14)

mouse (9)

Product Group

IHCPlus (1)

Isotype

IgG (11)

IgG1 (6)

IgG2a (2)

Clonality

monoclonal mc (8)

polyclonal pc (15)

Clone

OTI3C10 (2)

OTI4A2 (2)

OTI4H9 (2)

OTI6A6 (2)

Format

Biotin Conjugated (2)

Carrier-free (4)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (17)

Epitope

aa107-156 (4)

aa1-50 (1)

aa125-175 (1)

aa197-247 (1)

Publications

No (23)

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MMS21 / NSMCE2 Antibody (aa107-156) LS-B11627

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa107-156) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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MMS21 / NSMCE2 Antibody (aa107-156, HRP) LS-C460521

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa107-156) (HRP) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Gibbon, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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MMS21 / NSMCE2 Antibody (aa107-156, Biotin) LS-C460519

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa107-156) (Biotin) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Gibbon, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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MMS21 / NSMCE2 Antibody (aa107-156, FITC) LS-C460520

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa107-156) (FITC) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Gibbon, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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MMS21 / NSMCE2 Antibody (clone OTI6A6) LS-C115577

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (OTI6A6) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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MMS21 / NSMCE2 Antibody (clone OTI6A6, Carrier-free) LS-C784992

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (Carrier-free) (OTI6A6) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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MMS21 / NSMCE2 Antibody (clone OTI4A2) LS-C115574

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (OTI4A2) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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MMS21 / NSMCE2 Antibody (clone OTI4A2, Carrier-free) LS-C784988

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (Carrier-free) (OTI4A2) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MMS21 / NSMCE2 Antibody (clone OTI3C10) LS-C115575

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (OTI3C10) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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MMS21 / NSMCE2 Antibody (clone OTI3C10, Carrier-free) LS-C784989

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (Carrier-free) (OTI3C10) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MMS21 / NSMCE2 Antibody (clone OTI4H9) LS-C115576

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (OTI4H9) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

MMS21 / NSMCE2 Antibody (clone OTI4H9, Carrier-free) LS-C784990

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Monoclonal (Carrier-free) (OTI4H9) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MMS21 / NSMCE2 Antibody LS-C667265

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

MMS21 / NSMCE2 Antibody LS-C115838

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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MMS21 / NSMCE2 Antibody LS-C306664

Antibody:

MMS21 / NSMCE2 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

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MMS21 / NSMCE2 Antibody (aa1-50) LS-C290769

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

MMS21 / NSMCE2 Antibody LS-C807941

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MMS21 / NSMCE2 Antibody LS-C378370

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

MMS21 / NSMCE2 Antibody (HRP) LS-C378375

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

MMS21 / NSMCE2 Antibody (Biotin) LS-C378377

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

MMS21 / NSMCE2 Antibody (FITC) LS-C378374

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

MMS21 / NSMCE2 Antibody (aa125-175) LS-C290772

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa125-175) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

MMS21 / NSMCE2 Antibody (aa197-247) LS-C290773

Antibody:

MMS21 / NSMCE2 Rabbit anti-Human Polyclonal (aa197-247) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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