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MMS2 / UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
| Gene Name: | ubiquitin-conjugating enzyme E2 variant 2 |
| Synonyms: | UBE2V2, DDVit 1, EDPF1, EDAF-1, MMS2, MMS2 homolog, UEV-2, Vitamin D3-inducible protein, DDVit-1, DDVIT1, EDPF-1, UEV2 |
| Target Sequences: | NM_003350 NP_003341.1 Q15819 |
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