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MMP25 / Leukolysin

matrix metallopeptidase 25

MMP25 is a Metallopeptidase M10A type protease. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. Former prototype NM_022718.2 was permanently suppressed because currently there is insufficient support for the transcript. Caution: MMP25 has been referred to as MMP20; however, MMP20 is a distinct gene on human chromosome 11q22.

Gene Name: matrix metallopeptidase 25
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP25, Matrix metalloproteinase 25, MMP20A, MMPL1, MT6MMP, Matrix metallopeptidase 25, Matrix metallopeptidase-like 1, MMP-25, MT6-MMP, MTMMP6, Leukolysin, Matrix metalloproteinase 20, Matrix metalloproteinase-25, MT-MMP 6, MT-MMP6
Target Sequences: NM_022468 NP_071913.1 Q9NPA2

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Products
Antibodies (35)
Primary (35)
MMP25 / Leukolysin (35)
Human (35)
Mouse (12)
Rat (3)
Chimpanzee (3)
Gibbon (3)
Monkey (3)
Orangutan (3)
IHC (7)
WB (32)
Flo (5)
ELISA (9)
ICC (7)
IF (2)
IP (7)
Peptide-ELISA (1)
rabbit (27)
mouse (8)
IgG (12)
IgG2b,k (8)
monoclonal mc (8)
polyclonal pc (27)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (13)
aa470-499 (7)
aa235-284 (4)
No (35)
MMP25 / Leukolysin Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MMP25 / Leukolysin Antibody - The anti-MMP25 C-term Antibody is used in Western blot to detect MMP25 in mouse liver tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
MMP25 / Leukolysin Antibody - Immunohistochemistry of paraffin-embedded Rat spleen using MMP25 Polyclonal Antibody at dilution of 1:100 (40x lens).
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MMP25 / Leukolysin Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using MMP25 Polyclonal Antibody at dilution of 1:200 (40x lens).
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MMP25 / Leukolysin Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using MMP25 Polyclonal Antibody at dilution of 1:80.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MMP25 / Leukolysin Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer tissue.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$492; 1 ml/$563; 2 ml/$758; 5 ml/$1,233
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (HRP) Antibody
Human
ICC, IP, WB
HRP Conjugated
100 µl/$339; 200 µl/$394; 500 µl/$577; 1 ml/$705; 2 ml/$942; 5 ml/$1,603
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ICC, IP, WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$520; 1 ml/$598; 2 ml/$828; 5 ml/$1,356
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (FITC) Antibody
Human
ICC, IP, WB
FITC Conjugated
100 µl/$348; 200 µl/$408; 500 µl/$608; 1 ml/$758; 2 ml/$996; 5 ml/$1,725
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$492; 500 µl/$853; 1 ml/$1,013; 2 ml/$1,315; 5 ml/$2,465
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (APC, Cy7) Antibody
Human
ICC, IP, WB
APC, Cy7 Conjugated
100 µl/$506; 200 µl/$651; 500 µl/$1,156; 1 ml/$1,409; 2 ml/$1,972; 5 ml/$3,697
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (APC) Antibody
Human
ICC, IP, WB
APC Conjugated
100 µl/$407; 200 µl/$492; 500 µl/$853; 1 ml/$1,013; 2 ml/$1,315; 5 ml/$2,465
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Mouse anti-Human Monoclonal (Cy3) Antibody
Human
ICC, IP, WB
Cy3 Conjugated
100 µl/$407; 200 µl/$492; 500 µl/$853; 1 ml/$1,013; 2 ml/$1,315; 5 ml/$2,465
MMP25 / Leukolysin Antibody - Immunohistochemistry of paraffin-embedded Human brain using MMP25 Polyclonal Antibody at dilution of 1:80.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) (Biotin) Antibody
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) (FITC) Antibody
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) (PE) Antibody
Mouse, Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) (APC) Antibody
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa470-499) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
MMP25 / Leukolysin Antibody - MMP25 / Leukolysin antibody Western Blot of HeLa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal (aa235-284) Antibody
Human
WB
Unconjugated
100 µl/$424
MMP25 / Leukolysin Antibody - Western Blot; Sample: Recombinant MMP25, Human.
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MMP25 / Leukolysin Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).