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MMP14

matrix metallopeptidase 14 (membrane-inserted)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Gene Name: matrix metallopeptidase 14 (membrane-inserted)
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP14, Membrane type-1 MMP, MT1-MMP, MT1MMP, MT-MMP, MT-MMP 1, Matrix metalloproteinase-14, MMP-14, MMP-X1, MTMMP1
Target Sequences: NM_004995 NP_004986.1 P50281

Publications (2)

1
Cdc42-Dependent Transfer of mir301 from Breast Cancer-Derived Extracellular Vesicles Regulates the Matrix Modulating Ability of Astrocytes at the Blood-Brain Barrier. Golnaz Morad, Cassandra C Daisy, Hasan H Otu, Towia A Libermann, Simon T Dillon, Marsha A Moses. International journal of molecular sciences. 2020 May;21: [Full Text Article] [PubMed:32481745] [PMC:PMC7311991]
2
Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells. David J Lamb, Aleksander Rust, Albin Rudisch, Tobias Glüxam, Nathalie Harrer, Herwig Machat, Ingrid Christ, Florian Colbatzky, Andreas Wernitznig, Annika Osswald, Wolfgang Sommergruber. Oncotarget. 2020 Apr;11:1257-1272. [Full Text Article] [PubMed:32292575] [PMC:PMC7147091] Related Antibodies: LS-C8915.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
MMP14 (8)
No (8)
GST (1)
His, N-Terminal (1)
His-SUMO (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
MMP14 Protein - Recombinant Matrix Metalloproteinase 14 By SDS-PAGE
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E. coli
His, N-Terminal
45.9 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
MMP14 Protein
Select
E. coli
His-SUMO
69.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
MMP14 Protein - Recombinant Matrix Metalloproteinase 14 By SDS-PAGE
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E. coli
His-T7
25.2 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
MMP14 Protein - Purified recombinant protein MMP14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
53.8 kDa
20 µg/$1,107
MMP14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
65.89 kDa
20 µg/$150
MMP14 Protein - Recombinant Matrix Metalloproteinase 14 By SDS-PAGE
Select
E. coli
His-T7
29.3 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
MMP14 Protein - 12.5% SDS-PAGE of human MMP14 stained with Coomassie Blue
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Wheat Germ Extract
GST
92.3 kDa
2 µg/$439
MMP14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
65.89 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).