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MMP12

matrix metallopeptidase 12 (macrophage elastase)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene Name: matrix metallopeptidase 12 (macrophage elastase)
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP12, HME, Macrophage metalloelastase, Metalloelastase, MMP-12, ME, Macrophage elastase, Matrix metalloproteinase-12
Target Sequences: NM_002426 NP_002417.2 P39900

Publications (1)

1
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer. Pawel Bieniasz-Krzywiec, Rosa Martín-Pérez, Manuel Ehling, Melissa García-Caballero, Sotiria Pinioti, Samantha Pretto, Roel Kroes, Chiara Aldeni, Mario Di Matteo, Hans Prenen, María Virginia Tribulatti, Oscar Campetella, Ann Smeets, Agnes Noel, Giuseppe Floris, Jo A Van Ginderachter, Massimiliano Mazzone. The Breast : official journal of the European Society of Mastology. 2019 Nov;30:917-936.e10. [Full Text Article] [PubMed:31447322]

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Products
Antibodies (97)
Primary (97)
MMP12 (97)
Human (42)
Mouse (21)
Rat (42)
Monkey (2)
Rabbit (11)
IHC (14)
IHC-P (3)
WB (95)
ELISA (17)
ICC (3)
IF (3)
IP (2)
Peptide-ELISA (4)
rabbit (88)
goat (1)
guinea pig (8)
IgG (29)
polyclonal pc (97)
APC (7)
APC Conjugated (9)
Azide-free (1)
Biotin Conjugated (12)
Cy3 Conjugated (7)
Cy7 Conjugated (7)
FITC Conjugated (12)
HRP Conjugated (10)
PE Conjugated (9)
Unconjugated (31)
aa270-362 (10)
aa100-286 (8)
aa20-99 (8)
aa286-464 (8)
aa290-469 (8)
aa294-473 (8)
aa372-463 (8)
aa391-420 (7)
Internal (2)
60-140 aa, Internal (1)
Asp411 (1)
C-terminal (1)
Cleaved-Glu106 (1)
aa313-323 (1)
aa362-411 (1)
aa428-444 (1)
aa432-466 (1)
aa87-136 (1)
No (97)
MMP12 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MMP12 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MMP12 Antibody - Western blot of recombinant MMP12 / MMP-12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MMP12 Rabbit anti-Mouse Polyclonal (aa294-473) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
MMP12 Antibody - Western blot of recombinant MMP12 / MMP-12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MMP12 Rabbit anti-Mouse Polyclonal (aa294-473) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248
MMP12 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MMP12 Rabbit anti-Rat Polyclonal (aa270-362) Antibody
Rat
ICC, IHC-P, IP, WB
Unconjugated
50 µl/$460
MMP12 Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MMP12 Antibody at dilution of 1:100
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MMP12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
MMP12 Antibody - MMP12 antibody (0.5 ug/ml) staining of Human Breast Cancer lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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MMP12 Goat anti-Human Polyclonal (aa313-323) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
MMP12 Antibody - Western blot analysis of MMP12 expression in A549 (A); HEK293 (B); HeLa (C) whole cell lysates.
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MMP12 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
100 µl/$299
MMP12 Antibody - Western blot analysis of MMP12 expression in A549 (A); NIH3T3 (B) whole cell lysates.
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MMP12 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$321
MMP12 Antibody - Western blot of recombinant MMP12 / MMP-12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MMP12 Rabbit anti-Rat Polyclonal (aa100-286) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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MMP12 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P
Unconjugated
100 µl/$412
MMP12 Antibody - Western blot analysis of extracts of human heart, using MMP12 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
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MMP12 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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MMP12 Rabbit anti-Human Polyclonal (aa391-420) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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MMP12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
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MMP12 Rabbit anti-Human Polyclonal (C-terminal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MMP12 Antibody - Immunohistochemistry analysis of MMP-12 antibody in paraffin-embedded human lung carcinoma tissue.
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MMP12 Rabbit anti-Human Polyclonal (aa362-411) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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MMP12 Rabbit anti-Human Polyclonal (Asp411) Antibody
Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
MMP12 Antibody
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MMP12 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$575
MMP12 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer using MMP12 Polyclonal Antibody at dilution of 1:60.
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MMP12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MMP12 Antibody - antibody, PBMMP12, Western blot. All lanes: Anti MMP12 at 0.5 ug/ml. WB: HEPA Whole Cell Lysate at 40 ug. Predicted band size: 55 kD. Observed band size: 55 kD.
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MMP12 Rabbit anti-Mouse Polyclonal (aa432-466) Antibody
Mouse
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
MMP12 Antibody - Western blot analysis of extracts from NIH-3T3 cells, treated with etoposide (25uM, 1hour), using MMP12 (Cleaved-Glu106) antibody.
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MMP12 Rabbit anti-Human Polyclonal (Cleaved-Glu106) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).