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MMP1

matrix metallopeptidase 1 (interstitial collagenase)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Gene Name: matrix metallopeptidase 1 (interstitial collagenase)
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP1, CLG, Matrix metalloprotease 1, MMP-1, Interstitial collagenase, Matrix metalloproteinase 1, Matrix metalloproteinase-1
Target Sequences: NM_002421 NP_002412.1 P03956

Publications (3)

1
Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10<sub>) on Human Dermal Fibroblasts. Park SY, Byun EJ, Lee JD, Kim S, Kim HS. International journal of molecular sciences. 2018 September;19:pii E2727. [Full Text Article] [PubMed:30213068] [PMC:PMC6163910]
2
BRCA1 mutation influences progesterone response in human benign mammary organoids. Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E Clare, Seema A Khan, J Julie Kim. Breast cancer research : BCR. 2019 Nov;21:124. [Full Text Article] [PubMed:31771627] [PMC:PMC6878650]
3
Vitamin D and circulating tumor cells in primary breast cancer. Michal Mego, Barbora Vlkova, Gabriel Minarik, Zuzana Cierna, Marian Karaba, Juraj Benca, Tatiana Sedlackova, Dana Cholujova, Paulina Gronesova, Katarina Kalavska, Daniel Pindak, Jozef Mardiak, Peter Celec. Frontiers in oncology. 2022 September;12:950451. [Full Text Article] [PubMed:36158648] [PMC:PMC9489852]

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (2)
Recombinant (16)
MMP1 (18)
No (18)
6His, C-terminus (2)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (4)
His, N-Terminal (2)
His-S (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Bovine (1)
Human (14)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (9)
HEK 293 Cells (3)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (5)
Low endotoxin level (5)
Biologically active (1)
MMP1 Protein - Recombinant Matrix Metalloproteinase 1 (MMP1) by SDS-PAGE
Select
E. coli
His, N-Terminal
23.8kDa
10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
42.7 kDa
2 µg/$268; 10 µg/$349
MMP1 Protein - Recombinant Matrix Metalloproteinase 1 By SDS-PAGE
Select
E. coli
His
21.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
MMP1 Protein - Purified recombinant protein MMP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
51.8 kDa
20 µg/$1,107
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.88kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
MMP1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
54.01 kDa
20 µg/$150
MMP1 Protein - Recombinant  Matrix Metalloproteinase 1 By SDS-PAGE
Select
E. coli
His-S
55.1 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
MMP1 Protein - Recombinant Matrix Metalloproteinase 1 By SDS-PAGE
Select
E. coli
His-T7
37.7 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Select
E. coli
His
46.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
MMP1 Protein - 12.5% SDS-PAGE of human MMP1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
80.4 kDa
2 µg/$439
MMP1 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
56 kDa
10 µg/$265
MMP1 Protein
Select
E. coli
His, N-Terminal
51.8 kDa
50 µg/$419
MMP1 Protein - Human MMP-1 (~54 kD) was activated by 1 mM of p-Aminophenylmercuric acetate (APMA) at different time points at 37°C. After 1 h of activation, the mature form hMMP-1 (~45 kD) could be readily observed. Samples at reducing and non-reducing condition were resolved in a SDS-PAGE. Molecular weight markers at 250, 150, 100, 70, 55 kD were labeled here. Protein per lane: 2.5 µg
Select
HEK 293 Cells
None
Less than 1 EU/µg (determined by LAL method).
Predicted molecular mass of approximately 54 kD. The protein migrates at about 55 kD in DTT-reducing conditions and about 60 kD in non-reducing condition by SDS-PAGE.The N-terminal amino acid is Histidine.
10 µg/$355; 25 µg/$497; 500 µg/$3,043
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.88 kDa
10 µg/$344; 50 µg/$584
MMP1 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
50-55 kDa
20 µg/$515; 100 µg/$1,137
MMP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
54.01 kDa
100 µg/$494
Viewing 1-18 of 18 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).