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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
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MME / CD10

membrane metallo-endopeptidase

MME / CD10 is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Gene Name: membrane metallo-endopeptidase
Family/Subfamily: Protease , Metallopeptidase M13
Synonyms: MME, Atriopeptidase, CALLA, CD10, EPN, Membrane metallo-endopeptidase, NEP, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11, CD10 antigen, Enkephalinase, Neprylisin, SFE, Skin fibroblast elastase
Target Sequences: NM_000902 NP_000893.2 P08473

Publications (1)

1
A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M, Sandy AR, McCune WJ, Kaplan MJ. Journal of immunology (Baltimore, Md. : 1950). 2010 184:3284-97. [PubMed:20164424] [PMC:PMC2929645] Related Antibodies: LS-C41007.

☰ Filters
IHC (80)
IHC-P (36)
WB (146)
Flo (103)
ELISA (43)
ICC (2)
IF (17)
IP (25)
PMA (2)
rabbit (102)
mouse (139)
No (240)
Yes (1)
Viewing 1-25 of 241 items
MME / CD10 Antibody - Anti-CD10 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Cancer
Mouse Monoclonal [clone 56C6] (IgG1) to Human MME / CD10
Rat, Human
IHC, IHC-P
Unconjugated
0.1ml   $785.00
MME / CD10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Mouse Monoclonal [clone 56C6] (IgG1) to Human MME / CD10
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1ml   $250.00
MME / CD10 Antibody - Anti-MME / CD10 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Cancer
Rabbit Polyclonal [clone G27-P] to Human MME / CD10
Human
IHC, IHC-Fr, IHC-P
Unconjugated
100µl   $250.00
MME / CD10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Human MME / CD10
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200µl   $425.00
MME / CD10 Antibody - Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal [clone E19-P] to Human MME / CD10
IHC, IHC-P
Unconjugated
100µl   $425.00
MME / CD10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human MME / CD10
Mouse, Rat, Human
ELISA, IHC-P
Unconjugated
60µl   0.5mg/ml   $425.00
Select
Mouse Monoclonal [clone MEM-78] (IgG1) to Human MME / CD10
Human
Flo, IP
Biotin Conjugated
0.1mg   1mg/ml   $290.00
MME / CD10 Antibody - Nalm-6 cell line stained with purified HI10a and detected with anti-mouse IgGs-FITC
Select
(1) Publication(s)
Mouse Monoclonal [clone HI10a] (IgG1) to Human MME / CD10
Human, Monkey, Baboon
Flo
Unconjugated
100µg   0.5mg/ml   $225.00
MME / CD10 Antibody - IHC of paraffin-embedded prostate cancer tissues using CD10 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 7D4B1] (IgG1) to Human MME / CD10
Human
ELISA, IHC, WB
Unconjugated
100µg   1mg/ml   $365.00
Select
Mouse Monoclonal (IgG1) to Human MME / CD10
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl   $445.00
Select
Mouse Monoclonal [clone SN5c] (IgG1) to Human MME / CD10
Human
Flo, IHC-Fr, IP, WB
Unconjugated
100µg   1mg/ml   $265.00
MME / CD10 Antibody
Select
Mouse Monoclonal [clone 2A1H5E1] (IgG2b) to Human MME / CD10
Human
ELISA, IHC
Unconjugated
100µg   1mg/ml   $315.00
MME / CD10 Antibody - Immunofluorescence staining of MME in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-human MME monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Cell membrane.
Select
Rabbit Monoclonal [clone 113] (IgG) to Human MME / CD10
Human
ICC, IF
Unconjugated, Preservative Free
50µl   $245.00; 100µl   $305.00
Select
Mouse Monoclonal [clone SS2/36] (IgG1,k) to Human MME / CD10
Human
IHC, IHC-Fr
Unconjugated
500µl   $225.00
Select
Mouse Monoclonal (IgG1,k) to Human MME / CD10
Human
Flo, WB
Biotin Conjugated
100µg   $495.00
Select
Rabbit Polyclonal (IgG) to Rat MME / CD10
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl   $665.00
MME / CD10 Antibody - Surface staining of human peripheral blood with anti-human CD10 (MEM-78) APC.
Select
Mouse Monoclonal [clone MEM-78] (IgG1) to Human MME / CD10
Human
Flo, IP
APC Conjugated
100tst   $315.00
MME / CD10 Antibody - Immunohistochemical staining of paraffin-embedded Raji cell pellets using anti-MME. (CD10) mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH9.0) at 120°C for 2.5 min. (1:600)
Select
Mouse Monoclonal [clone UMAB236] (IgG1) to Human MME / CD10
Human
Flo, IHC, PMA, WB
Unconjugated
100µl   $395.00
MME / CD10 Antibody - Immunohistochemical staining of paraffin-embedded Raji cell pellets using anti-MME. (CD10) mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH9.0) at 120°C for 2.5 min. (1:600)
Select
Mouse Monoclonal [clone UMAB236] (IgG1) to Human MME / CD10
Human
Flo, IHC, PMA, WB
Unconjugated, Carrier-free
100µg   $425.00
MME / CD10 Antibody - MME/CD10 western blot of CEM cell line lysates (35 ug/lane). The MME/CD10 antibody detected the MME/CD10 protein (arrow).
Select
Mouse Monoclonal (IgM,k) to Human MME / CD10
Human
WB
Unconjugated
400µl   $325.00
MME / CD10 Antibody - Staining of normal human peripheral blood cells with PE Mouse IgG2b isotype control (open histogram) or PE anti-human CD10 (CB-CALLA) (colored histogram). Cells in the granulocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone CB-CALLA] (IgG2b) to Human MME / CD10
Human
Flo
PE Conjugated
25tst   $225.00; 100tst   $345.00
MME / CD10 Antibody - MME / CD10 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human MME / CD10
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
MME / CD10 Antibody - Western blot of recombinant MME / CD10.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human MME / CD10
Mouse, Rat, Human
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $295.00; 1ml   0.5mg/ml   $495.00
Select
Mouse Monoclonal [clone 3G6B11] (IgG1) to Human MME / CD10
Human
ELISA, Flo, IHC, WB
Unconjugated
100µl   $365.00
Select
Mouse Monoclonal (IgG2a) to Human MME / CD10
Human
ELISA, Flo, IHC, WB
Unconjugated
100µg   $335.00

Viewing 1-25 of 241 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).