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MLKL

mixed lineage kinase domain-like

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Gene Name: mixed lineage kinase domain-like
Family/Subfamily: Protein Kinase , Provisional protein kinase
Synonyms: MLKL
Target Sequences: NM_152649 NP_689862.1 Q8NB16

Publications (4)

1
RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. Sureshbabu A, Patino E, Ma KC, Laursen K, Finkelsztein EJ, Akchurin O, Muthukumar T, Ryter SW, Gudas L, Choi AMK, Choi ME. JCI insight. 2018 June;3:pii: 98411. [Full Text Article] [PubMed:29875323] [PMC:PMC6124406]
2
Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells. Van Hoecke L, Raes L, Stremersch S, Brans T, Fraire JC, Roelandt R, Declercq W, Vandenabeele P, Raemdonck K, Braeckmans K, Saelens X. International journal of molecular sciences. 2019 August;20:E4254. [Full Text Article] [PubMed:31480289] [PMC:PMC6747363]
3
Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies. Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P Wicks, Hitoshi Kohsaka, Shinsuke Yasuda. Nature communications. 2022 January;13:166. [Full Text Article] [PubMed:35013338] [PMC:PMC8748624]
4
Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy. Jia Guo, Zehui Guo, Yanju Huang, Suchen Ma, Bo Yan, Chenjie Pan, Zhaodi Jiang, Fengchao Wang, Zhiyuan Zhang, Yuwei Da, Xiaodong Wang, Zhengxin Ying. Proceedings of the National Academy of Sciences of the United States of America. 2022 April;119:e2121552119. [Full Text Article] [PubMed:35344427] [PMC:PMC9168919]
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Proteins (6)
Recombinant (6)
MLKL (6)
No (5)
Yes (1)
6His, N-terminus (3)
GST (1)
GST, N-terminus (1)
His-SUMO (1)
Human (5)
Mouse (1)
E. coli (2)
Wheat Germ Extract (2)
Yeast (2)
Purified (2)
MLKL Protein
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Yeast
6His, N-terminus
56.3 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
MLKL Protein
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Yeast
6His, N-terminus
56.48 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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E. coli
His-SUMO
70.44 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
MLKL Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
58.5 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
MLKL Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MLKL Protein - 12.5% SDS-PAGE of human MLKL stained with Coomassie Blue
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Wheat Germ Extract
GST
80.9 kDa
2 µg/$439
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).