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Unfortunately, the antibody (ID:73337) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



MLH1

mutL homolog 1

Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.

Gene Name: mutL homolog 1
Synonyms: MLH1, COCA2, FCC2, HMLH1, HNPCC, HNPCC2, MutL protein homolog 1
Target Sequences: NM_000249 NP_000240.1 P40692

Publications (1)

1
An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family. Meyer C, Brieger A, Plotz G, Weber N, Passmann S, Dingermann T, Zeuzem S, Trojan J, Marschalek R. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:762-9. (WB; Human) [PubMed:19188145]

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
MLH1 Mouse IgG1 Monoclonal Unconjugated Human, Monkey IHC-P, IF, WB, ELISA
1
MLH1 Mouse IgG1 Monoclonal Unconjugated Human, Monkey IHC-P, IF, WB, ELISA No Primary
Anti-MLH1 Antibody IHC-plus™ LS-B3475
Immunohistochemistry Image
Immunofluorescence Image
Mouse Monoclonal (IgG1) to Human MLH1
Human, Monkey
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human IHC-P Internal
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human IHC-P Internal No Primary
Anti-MLH1 Antibody (Internal) LS-C210492
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human MLH1
Human
IHC - Paraffin
Unconjugated
MLH1 Mouse IgG Monoclonal M1 Unconjugated Human IF, WB, ELISA
1
MLH1 Mouse IgG Monoclonal M1 Unconjugated Human IF, WB, ELISA No Primary
Anti-MLH1 Antibody (clone M1) LS-C133324
Immunofluorescence Image
Western blot Image
Mouse Monoclonal [clone M1] (IgG) to Human MLH1
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human ICC, IF, WB
1
MLH1 Rabbit Polyclonal Unconjugated Human ICC, IF, WB No Primary
Anti-MLH1 Antibody LS-C109333
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal to Human MLH1
Human
ICC, Immunofluorescence, Western blot
Unconjugated
MLH1 Mouse IgG2a Monoclonal G168-728 Unconjugated Human IHC-P, IHC-Fr
1
MLH1 Mouse IgG2a Monoclonal G168-728 Unconjugated Human IHC-P, IHC-Fr No Primary
Anti-MLH1 Antibody (clone G168-728) LS-C312102
Immunohistochemistry Image
Mouse Monoclonal [clone G168-728] (IgG2a) to Human MLH1
Human
IHC - Paraffin, IHC - Frozen
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human IHC, IF, WB, Flo aa466-496
1
MLH1 Rabbit Polyclonal Unconjugated Human IHC, IF, WB, Flo aa466-496 No Primary
Anti-MLH1 Antibody (aa466-496) LS-C164216
Immunohistochemistry Image
Immunofluorescence Image
Rabbit Polyclonal to Human MLH1
Human
IHC, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
MLH1 Mouse IgG1 Monoclonal G168-15 Unconjugated Human, Rat, Hamster IHC-P
1
MLH1 Mouse IgG1 Monoclonal G168-15 Unconjugated Human, Rat, Hamster IHC-P No Primary
Anti-MLH1 Antibody (clone G168-15) LS-C95607
Mouse Monoclonal [clone G168-15] (IgG1)
Human, Rat, Hamster
IHC - Paraffin
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human ICC, IF, WB Internal
1
MLH1 Rabbit Polyclonal Unconjugated Human ICC, IF, WB Internal No Primary
Anti-MLH1 Antibody (Internal) LS-C352510
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal to Human MLH1
Human
ICC, Immunofluorescence, Western blot
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA N-Terminus
1
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA N-Terminus No Primary
Anti-MLH1 Antibody (N-Terminus) LS-C414801
Rabbit Polyclonal to Human MLH1
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated, Azide-free,Biotin Conjugated,FITC Conjugated,PE Conjugated,APC Conjugated,AP Conjugated Human WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA aa459-488
7
MLH1 Rabbit IgG Polyclonal Unconjugated Human WB, Flo, ELISA aa459-488 No Primary
Anti-MLH1 Antibody (aa459-488) LS-C323025
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
Unconjugated
MLH1 Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human WB, Flo, ELISA aa452-480 No Primary
Anti-MLH1 Antibody (aa452-480, Azide-free, HRP) LS-C263234
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
HRP Conjugated, Azide-free
MLH1 Rabbit IgG Polyclonal Biotin Conjugated Human WB, Flo, ELISA aa452-480 No Primary
Anti-MLH1 Antibody (aa452-480, Biotin) LS-C263229
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
Biotin Conjugated
MLH1 Rabbit IgG Polyclonal FITC Conjugated Human WB, Flo, ELISA aa452-480 No Primary
Anti-MLH1 Antibody (aa452-480, FITC) LS-C263231
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
FITC Conjugated
MLH1 Rabbit IgG Polyclonal PE Conjugated Human WB, Flo, ELISA aa452-480 No Primary
Anti-MLH1 Antibody (aa452-480, PE) LS-C263235
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
PE Conjugated
MLH1 Rabbit IgG Polyclonal APC Conjugated Human WB, Flo, ELISA aa452-480 No Primary
Anti-MLH1 Antibody (aa452-480, APC) LS-C263228
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
APC Conjugated
MLH1 Rabbit IgG Polyclonal AP Conjugated Human WB, Flo, ELISA aa452-480 No Primary
Anti-MLH1 Antibody (aa452-480, AP) LS-C263230
Rabbit Polyclonal (IgG) to Human MLH1
Human
Western blot, Flow Cytometry, ELISA
AP Conjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF, WB, ELISA aa410-490
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF, WB, ELISA aa410-490 No Primary
Anti-MLH1 Antibody (aa410-490) LS-C384568
Western blot Image
Western blot Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat
Immunofluorescence, Western blot, ELISA
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF, WB
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF, WB No Primary
Anti-MLH1 Antibody LS-C330874
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
MLH1 Mouse Monoclonal Unconjugated Human ICC, WB
1
MLH1 Mouse Monoclonal Unconjugated Human ICC, WB No Primary
Anti-MLH1 Antibody LS-C342042
Mouse Monoclonal to Human MLH1
Human
ICC, Western blot
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ELISA
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ELISA No Primary
Anti-MLH1 Antibody LS-C400894
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat
IHC, ELISA
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IF, WB Ser467
1
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IF, WB Ser467 No Primary
Anti-MLH1 Antibody (Ser467) LS-C176980
Western blot Image
Rabbit Polyclonal to Human MLH1
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ELISA
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ELISA No Primary
Anti-MLH1 Antibody LS-C404150
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat
IHC, ELISA
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human WB, Flo aa452-480
1
MLH1 Rabbit Polyclonal Unconjugated Human WB, Flo aa452-480 No Primary Available
Anti-MLH1 Antibody (aa452-480) LS-C164215
Western blot Image
Flow Cytometry Image
Rabbit Polyclonal to Human MLH1
Human
Western blot, Flow Cytometry
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human IHC-Fr, WB, IP
1
MLH1 Rabbit Polyclonal Unconjugated Human IHC-Fr, WB, IP No Primary
Anti-MLH1 Antibody LS-C9064
Rabbit Polyclonal to Human MLH1
Human
IHC - Frozen, Western blot, Immunoprecipitation
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA
1
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA No Primary
Anti-MLH1 Antibody LS-C413747
Rabbit Polyclonal to Human MLH1
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Dog, Pig, Chicken, Xenopus WB, IP, PLA C-Terminus
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Dog, Pig, Chicken, Xenopus WB, IP, PLA C-Terminus No Primary
Anti-MLH1 Antibody (C-Terminus) LS-C286959
Western blot Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat, Bovine, Dog, Pig, Chicken, Xenopus
Western blot, Immunoprecipitation, Proximity Ligation Assay
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA aa441-490
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA aa441-490 No Primary
Anti-MLH1 Antibody (aa441-490) LS-C119574
Western blot Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
MLH1 Mouse IgG2a Monoclonal G168-728 Unconjugated, Ready-to-Use Human IHC-P, IHC-Fr
1
MLH1 Mouse IgG2a Monoclonal G168-728 Unconjugated, Ready-to-Use Human IHC-P, IHC-Fr No Primary
Anti-MLH1 Antibody (clone G168-728, Ready-to-Use) LS-C348524
Immunohistochemistry Image
Mouse Monoclonal [clone G168-728] (IgG2a) to Human MLH1
Human
IHC - Paraffin, IHC - Frozen
Unconjugated, Ready-to-Use
MLH1 Mouse IgG Monoclonal MTLH1-1 Unconjugated, Azide-free Human WB
1
MLH1 Mouse IgG Monoclonal MTLH1-1 Unconjugated, Azide-free Human WB No Primary
Anti-MLH1 Antibody (clone MTLH1-1, Azide-free) LS-C490020
Mouse Monoclonal [clone MTLH1-1] (IgG) to Human MLH1
Human
Western blot
Unconjugated, Azide-free
MLH1 Mouse IgG Monoclonal MTLH1-1 Unconjugated Human WB
1
MLH1 Mouse IgG Monoclonal MTLH1-1 Unconjugated Human WB No Primary
Anti-MLH1 Antibody (clone MTLH1-1) LS-C489985
Mouse Monoclonal [clone MTLH1-1] (IgG) to Human MLH1
Human
Western blot
Unconjugated
MLH1 Mouse IgG Monoclonal 164C819 Unconjugated Human, Monkey WB aa387-403
1
MLH1 Mouse IgG Monoclonal 164C819 Unconjugated Human, Monkey WB aa387-403 No Primary
Anti-MLH1 Antibody (aa387-403, clone 164C819) LS-C566
Western blot Image
Mouse Monoclonal [clone 164C819] (IgG) to Human MLH1
Human, Monkey
Western blot
Unconjugated
MLH1 Mouse IgG1 Monoclonal Unconjugated Human WB aa458-489
1
MLH1 Mouse IgG1 Monoclonal Unconjugated Human WB aa458-489 No Primary
Anti-MLH1 Antibody (aa458-489) LS-C158152
Western blot Image
Mouse Monoclonal (IgG1) to Human MLH1
Human
Western blot
Unconjugated
MLH1 Mouse Monoclonal Unconjugated Human WB
1
MLH1 Mouse Monoclonal Unconjugated Human WB No Primary
Anti-MLH1 Antibody LS-C393633
Western blot Image
Mouse Monoclonal to Human MLH1
Human
Western blot
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish WB,WB,WB,WB aa35-84
4
MLH1 Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish WB aa35-84 No Primary Available
Anti-MLH1 Antibody (aa35-84) LS-C111793
Western blot Image
Rabbit Polyclonal to Human MLH1
Human, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish
Western blot
Unconjugated
MLH1 Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish WB aa35-84 No Primary
Anti-MLH1 Antibody (aa35-84, HRP) LS-C461098
Western blot Image
Rabbit Polyclonal to Human MLH1
Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish
Western blot
HRP Conjugated
MLH1 Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish WB aa35-84 No Primary
Anti-MLH1 Antibody (aa35-84, Biotin) LS-C461096
Western blot Image
Rabbit Polyclonal to Human MLH1
Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish
Western blot
Biotin Conjugated
MLH1 Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish WB aa35-84 No Primary
Anti-MLH1 Antibody (aa35-84, FITC) LS-C461097
Western blot Image
Rabbit Polyclonal to Human MLH1
Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish
Western blot
FITC Conjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse WB aa722-756
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse WB aa722-756 No Primary
Anti-MLH1 Antibody (aa722-756) LS-C407936
Western blot Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse
Western blot
Unconjugated
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB
1
MLH1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB No Primary
Anti-MLH1 Antibody LS-C490397
Western blot Image
Rabbit Polyclonal (IgG) to Human MLH1
Human, Mouse, Rat
Western blot
Unconjugated
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB
1
MLH1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB No Primary
Anti-MLH1 Antibody LS-C192641
Western blot Image
Rabbit Polyclonal to Human MLH1
Human, Mouse, Rat
Western blot
Unconjugated
MLH1 Mouse IgG1 Monoclonal 1C1 Unconjugated Human IHC-P aa299-527
1
MLH1 Mouse IgG1 Monoclonal 1C1 Unconjugated Human IHC-P aa299-527 No Primary
Anti-MLH1 Antibody (aa299-527, clone 1C1) LS-C339449
Immunohistochemistry Image
Mouse Monoclonal [clone 1C1] (IgG1) to Human MLH1
Human
IHC - Paraffin
Unconjugated
MLH1 Rabbit Polyclonal Agarose Conjugated Human IP C-Terminus
1
MLH1 Rabbit Polyclonal Agarose Conjugated Human IP C-Terminus No Primary
Anti-MLH1 Antibody (C-Terminus, Agarose) LS-C291102
Rabbit Polyclonal to Human MLH1
Human
Immunoprecipitation
Agarose Conjugated
Target Corresponding Antibodies
MLH1
1
MLH1 Antibody Blocking Peptide - LS-E1153
LS-E1153
MLH1
LS-C164215
MLH1
1
MLH1 Antibody Blocking Peptide - LS-E20303
LS-E20303
MLH1
LS-C111793
Type Target Reactivity Sample Type
Sandwich MLH1 Human Cell Lysates, Tissue Homogenates
1
Human MLH1 ELISA Kit (Sandwich ELISA) - LS-F8678
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Human
0.156-10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant MLH1 GST Human Wheat Purified
1
Human MLH1 Protein (Recombinant GST) - LS-G29342
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Wheat Wheat Germ Extract
756 AA
GST
Purified
108.9 kDa

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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