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MKX

mohawk homeobox

MKX is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: mohawk homeobox
Synonyms: MKX, Homeobox protein Mohawk, IFRX, Mohawk homeobox, C10orf48, IRXL1
Target Sequences: NM_173576 NP_775847.2 Q8IYA7

Publications (8)

1
Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, Muneta T, Lotz M, Asahara H. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2015 33:1-8. (WB; Human) [Full Text Article] [PubMed:25312837] [PMC:PMC4294629]
2
Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H. Nature communications. 2016 7:12503. (IHC, WB, ELISA; Human) [Full Text Article] [PubMed:27527664] [PMC:PMC4990710]
3
Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties. Zarychta-Wisniewska W, Burdzinska A, Kulesza A, Gala K, Kaleta B, Zielniok K, Siennicka K, Sabat M, Paczek L. BMC cell biology. 2017 18:13. (WB; Human) [Full Text Article] [PubMed:28214472] [PMC:PMC5316159] Related Antibodies: LS-C164212.
4
Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling. Wang Y, Zhang X, Huang H, Xia Y, Yao Y, Mak AF, Yung PS, Chan KM, Wang L, Zhang C, Huang Y, Mak KK. eLife. 2017 6: (WB; Human) [Full Text Article] [PubMed:29244023] Related Antibodies: LS-B8063.
5
The Influence of Cell Source and Donor Age on the Tenogenic Potential and Chemokine Secretion of Human Mesenchymal Stromal Cells. Weronika Zarychta-Wisniewska, Anna Burdzinska, Katarzyna Zielniok, Marta Koblowska, Kamila Gala, Piotr Pedzisz, Roksana Iwanicka-Nowicka, Anna Fogtman, Aleksandra Aksamit, Agnieszka Kulesza, Aleksandra Zolocinska, Leszek Paczek. Stem cells international. 2019 June;2019:1613701. [Full Text Article] [PubMed:31205472] [PMC:PMC6530320] Related Antibodies: LS-C164212.
6
Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage. Yusuke Ogata, Yo Mabuchi, Kosuke Shinoda, Yuta Horiike, Mitsuru Mizuno, Koji Otabe, Eriko Grace Suto, Nobuharu Suzuki, Ichiro Sekiya, Chihiro Akazawa. Regenerative therapy. 2018 Jan;8:20-28. [Full Text Article] [PubMed:30271862] [PMC:PMC6149186]
7
Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, Ozaki T, Lotz MK, Asahara H. Arthritis and rheumatism. 2013 Aug;65:2081-9. (WB; Human) [Full Text Article] [PubMed:23686683] [PMC:PMC3840305] Related Antibodies: LS-B8063.
8
Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGF beta signaling pathway. Liu H, Zhang C, Zhu S, Lu P, Zhu T, Gong X, Zhang Z, Hu J, Yin Z, Heng BC, Chen X, Wei Ouyang H. Stem cells (Dayton, Ohio). Feb;33:443-55. [Full Text Article] [PubMed:25332192] Related Antibodies: LS-B8063.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).