Mineralocorticoid Receptor

nuclear receptor subfamily 3, group C, member 2

The mineralocorticoid receptor (MR), a NR3 Steroid Receptor, has been shown to affect hypothalamic-pituitary-adrenocortical axis activity in the brain, sodium and potassium transport, and stress-related psychiatric diseases such as major depression. MR binds aldosterone and glucocorticoid with equal affinity, and the binding specificity is regulated by the enzyme 11beta-hydroxysteroid-dehydrogenase type II. Mutations in the mineralocorticoid receptor cause autosomal dominant pseudohypoaldosteronism type I and early onset hypertension. Three isoforms of MR have been documented in human: wild type, MR+4, which contains four additional amino acids in the DNA-binding domain due to alternative splicing between exons 3 and 4, and hMR delta5,6, resulting from an alternative-splicing event that skips exons 5 and 6 of the human MR gene.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

Mineralocorticoid Receptor (4)

Publications

No (4)

Tag

GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human Mineralocorticoid Receptor Protein (Recombinant His-GST) (aa739-984) - LS-G12195

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human Mineralocorticoid Receptor Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G59253

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human Mineralocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77376

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

20 µg/$215

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Mineralocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122936

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

100 µg/$710

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