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Mineralocorticoid Receptor
nuclear receptor subfamily 3, group C, member 2
The mineralocorticoid receptor (MR), a NR3 Steroid Receptor, has been shown to affect hypothalamic-pituitary-adrenocortical axis activity in the brain, sodium and potassium transport, and stress-related psychiatric diseases such as major depression. MR binds aldosterone and glucocorticoid with equal affinity, and the binding specificity is regulated by the enzyme 11beta-hydroxysteroid-dehydrogenase type II. Mutations in the mineralocorticoid receptor cause autosomal dominant pseudohypoaldosteronism type I and early onset hypertension. Three isoforms of MR have been documented in human: wild type, MR+4, which contains four additional amino acids in the DNA-binding domain due to alternative splicing between exons 3 and 4, and hMR delta5,6, resulting from an alternative-splicing event that skips exons 5 and 6 of the human MR gene.
| Gene Name: | nuclear receptor subfamily 3, group C, member 2 |
| Family/Subfamily: | NHR , NR3 Steroid receptor |
| Synonyms: | NR3C2, MCR, Mineralocorticoid receptor, NR3C2VIT, Aldosterone receptor, Mineralocorticoid receptor 1, MLR, MR |
| Target Sequences: | NM_000901 NP_000892.2 P08235 |
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