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Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Gene Name: | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
Synonyms: | MICAL2, KIAA0750, MICAL2PV2, MICAL-2, Protein MICAL-2, MICAL2PV1 |
Target Sequences: | NM_014632 NP_055447.1 O94851 |
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