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MICA

MHC class I polypeptide-related sequence A

MICA is the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: MHC class I polypeptide-related sequence A
Synonyms: MICA, HLA class I antigen, MIC-A, PERB11.1
Target Sequences: NM_000247 NP_000238.1 Q29983

Publications (2)

1
Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma. Marie-Claire Rittmann, Saskia Hussung , Lukas M Braun , Rhena F U Klar, Esther A Biesel, Stefan Fichtner-Feigl, Ralph Fritsch , Uwe A Wittel, Dietrich A Ruess. Scientific reports. 2021 Apr;11:7499. [Full Text Article] [PubMed:33820913] [PMC:PMC8021576]
2
Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy. van Esch EM, Tummers B, Baartmans V, Osse EM, Ter Haar N, Trietsch MD, Hellebrekers BW, Holleboom CA, Nagel HT, Tan LT, Fleuren GJ, van Poelgeest MI, van der Burg SH, Jordanova ES. International journal of cancer. Journal international du cancer. 2014 Aug;135:830-42. [Full Text Article] [PubMed:24415578] Related Antibodies: LS-B1377.

☰ Filters
Antibodies (45)
Proteins (14)
ELISA Kits (5)
Over-Expression Lysate (4)
Primary (45)
Recombinant (10)
Sandwich (5)
MICA (64)
Human (50)
Mouse (7)
Rat (3)
Chimpanzee (9)
Gibbon (3)
IHC (15)
IHC-P (5)
WB (39)
Flo (11)
ELISA (12)
ICC (5)
IF (8)
IP (1)
Peptide-ELISA (1)
rabbit (40)
mouse (5)
Product Group
IHCPlus (2)
IgG (33)
IgG1 (1)
monoclonal mc (4)
polyclonal pc (41)
96-Well Microplate (2)
96-Well Strip Plate (3)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
FITC Conjugated (6)
HRP Conjugated (5)
PE Conjugated (3)
Preservative Free (1)
Unconjugated (23)
aa68-97 (7)
aa110-159 (4)
aa201-250 (4)
aa41-90 (4)
aa24-307 (2)
aa1-308 (1)
aa304-334 (1)
No (62)
Yes (2)
Cell Culture Supernatants (3)
Cell Lysates (2)
Plasma (3)
Serum (5)
Tissue Homogenates (2)
6His, C-terminus (2)
Fc, C-terminus (3)
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His (2)
Myc-DDK (Flag) (6)
Human (12)
293T Cells (2)
E. coli (1)
HEK 293 Cells (4)
Human Cells (3)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (6)
Biologically active (1)
MICA Antibody - Anti-MICA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MICA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
MICA Protein - Purified recombinant protein MICA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
38.3 kDa
20 µg/$1,107
MICA Antibody - Anti-MICA antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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MICA Rabbit anti-Human Polyclonal (aa68-97) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
MICA Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.
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MICA Rabbit anti-Human Polyclonal (aa24-307) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
MICA Antibody - Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MICA Rabbit anti-Human Polyclonal (aa201-250) Antibody
Human
WB
Unconjugated
100 µl/$397
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MICA Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
25 Tests/$263; 100 Tests/$376
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MICA Rabbit anti-Human Polyclonal (aa68-97) Antibody
Human
Flo, IF, IHC, WB
Unconjugated
200 µl/$734
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MICA Rabbit anti-Human Polyclonal (aa68-97) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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MICA Rabbit anti-Human Polyclonal (aa68-97) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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MICA Rabbit anti-Human Polyclonal (aa68-97) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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MICA Rabbit anti-Human Polyclonal (aa68-97) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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MICA Rabbit anti-Human Polyclonal (aa68-97) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33.87kD
10 µg/$262; 50 µg/$372; 500 µg/$1,348; 1 mg/$1,716
MICA ELISA Kit
Select
Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Serum
1 Plate/$795
MICA ELISA Kit
Select
Sandwich
96-Well Microplate
Human
13.72 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
MICA Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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MICA Rabbit anti-Human Polyclonal (aa24-307) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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MICA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
MICA Antibody - Anti-MICA rabbit polyclonal antibody at 1:500 dilution. Lane A: 293T Whole Cell Lysate. Lane B: Jurkat Whole Cell Lysate. Lane C: Daudi Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 43 kDa. Observed band size: 55 kDa.
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MICA Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IHC-P, IP, WB
Unconjugated, Preservative Free
20 µl/$256; 100 µl/$412
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MICA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MICA Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using MICA Polyclonal Antibody at dilution of 1:60(×200)
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MICA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MICA Antibody - Western blot of extracts of various cell lines, using MICA antibody.
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MICA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
MICA Antibody - Immunohistochemistry of paraffin-embedded human stomach using MICA antibody at dilution of 1:100 (40x lens).
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MICA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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MICA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
Select
MICA Mouse anti-Human Monoclonal Antibody
Human
Flo
Unconjugated
100 µl/$412
MICA Antibody - Western blot analysis of A549 whole cells lysates using MICA antibody. The lane on the left is treated with the antigen-specific peptide.
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MICA Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25 of 64 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).