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Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
Gene Name: | methionyl aminopeptidase 1 |
Family/Subfamily: | Exopeptidase , Metallopeptidase M24A |
Synonyms: | METAP1, KIAA0094, MetAP 1, Peptidase M 1, MAP 1, Methionine aminopeptidase 1, MetAP1A, Methionyl aminopeptidase 1 |
Target Sequences: | NM_015143 NP_055958.2 P53582 |
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