MER / MERTK

c-mer proto-oncogene tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

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Products

Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

MER / MERTK (14)

Publications

No (14)

Tag

6His, C-terminus (1)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc, C-terminus (1)

Fc-His, C-terminus (1)

GST, N-terminus (1)

His (1)

His,C-terminus (1)

His,N-terminus + GST (1)

His-GST (1)

Myc-DDK (Flag) (3)

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Species

Human (11)

Mouse (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (6)

Human Cells (1)

Insect Cells (1)

Mammalian Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (7)

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Mouse MER / MERTK Protein (Recombinant Fc, C-terminus) (Met1-Phe498) - LS-G138508

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

79.3 kDa

Price:

100 µg/$502

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Human MER / MERTK Protein (Recombinant) (Met1-Ala499) - LS-G137973

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

54 kDa

Price:

100 µg/$926

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Human MER / MERTK Protein (Recombinant Fc-His, C-terminus) (Met1-Ala499) - LS-G138484

Source:

HEK 293 Cells

Tag:

Fc-His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80 kDa

Price:

100 µg/$502

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Human MER / MERTK Protein (Recombinant GST, N-terminus) (aa21-120) - LS-G61517

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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MER / MERTK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115374

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110.25 kDa

Price:

100 µg/$710

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Human MER / MERTK Protein (Recombinant His,N-terminus + GST) (Glu578-Tyr872) - LS-G140009

Source:

Insect Cells

Tag:

His,N-terminus + GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

62 kDa

Price:

50 µg/$707

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Human MER / MERTK Protein (Recombinant DDK,C-terminus) - LS-G142371

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

52.6 kDa

Price:

20 µg/$677

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Human MER / MERTK Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142230

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

55 kDa

Price:

20 µg/$1,107

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Human MER / MERTK Protein (Recombinant His) (aa587-858) - LS-G25453

Source:

E. coli

Tag:

His

Molecular Weight:

35.0 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human MER / MERTK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67230

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108 kDa

Price:

20 µg/$1,107

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Mouse MER / MERTK Protein (Recombinant His-GST) (Glu573-Tyr867) - LS-G98216

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

61.7 kDa

Price:

50 µg/$707

Select

Human MER / MERTK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79387

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

110.25 kDa

Price:

20 µg/$215

Select

Human MER / MERTK Protein (Recombinant His,C-terminus) (Met177-Ala499) - LS-G140529

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36 kDa

Price:

10 µg/$317; 50 µg/$524

Select

Human MER / MERTK Protein (Recombinant 6His, C-terminus) (Met177-Ala499) - LS-G39957

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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