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MEGF10

multiple EGF-like-domains 10

Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway.

Gene Name: multiple EGF-like-domains 10
Synonyms: MEGF10, EMARDD, KIAA1780, Multiple EGF-like-domains 10
Target Sequences: NM_032446 NP_115822.1 Q96KG7

Publications (1)

1
Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame. Shohei Wakao, Yo Oguma, Yoshihiro Kushida, Yasumasa Kuroda, Kazuki Tatsumi, Mari Dezawa. Cellular and molecular life sciences : CMLS. 2022 October;79:542. [Full Text Article] [PubMed:36203068] [PMC:PMC9537123] Related Antibodies: LS-C668447.

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Proteins (3)
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MEGF10 (3)
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MEGF10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
122 kDa
20 µg/$215
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
90.2 kDa
100 µg/$843
MEGF10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
122 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).